CLL-specific scientific studies & literature related to COVID-19
In this section you will find a compilation of scientific studies and articles from the literature on COVID-19 relevant to CLL patients.
If you know about any current or published study on CLL and COVID-19, please let us know by sending us an email.

First published: 20 July 2020
Outcomes of COVID-19 in Patients with CLL: A Multicenter, International Experience
Clinical Trials & Observations
Anthony R. Mato, Lindsey Elizabeth Roeker, Nicole Lamanna, John Allan, Lori Ann Leslie, John M. Pagel, Krish Patel, Anders Osterborg, Daniel Wojenski, Manali Kamdar, Scott F Huntington, Matthew S. Davids, Jennifer R. Brown, Darko Antic, Ryan W Jacobs, Inhye E Ahn, Jeffrey J Pu, Krista Isaac, Paul M. Barr, Chaitra Ujjani, Mark Blaine Geyer, Ellin Berman, Andrew D. Zelenetz, Nikita Malakhov, Richard R. Furman, Michael Koropsak, Neil Bailey, Lotta Hansson, Guilherme Fleury Perini, Shuo Ma, Christine E. Ryan, Adrian Wiestner, Craig A Portell, Mazyar Shadman, Elise A. Chong, Danielle M. Brander, Suchitra Sundaram, Amanda N. Seddon, Erlene Seymour, Meera Patel, Nicolas Martinez-Calle, Talha Munir, Renata Walewska, Angus Broom, Harriet Sarah Walter, Dima El-Sharkawi, Helen Parry, Matthew R. Wilson, Piers E Patten, José-Ángel Hernández-Rivas, Fatima Miras, Noemi Fernández Escalada, Paola Ghione, Chadi Nabhan, Sonia Lebowitz, Erica B Bhavsar, Javier López-Jiménez, Daniel Naya, Jose Antonio Garcia-Marco, Sigrid S Skånland, Raul Cordoba, Toby Andrew Eyre
KEY POINTS:
- Both watch and wait and treated CLL patients when admitted for COVID-19 have high mortality rates.
- Receiving a BTKi for CLL at COVID-19 diagnosis severe enough to require hospitalization did not influence case fatality rate in this study
This ASH paper is the largest multicentre study to date in CLL!
Please access the full article here.

First published: 9 July 2020
COVID-19 severity and mortality in patients with chronic lymphocytic leukemia: a joint study by ERIC, the European Research Initiative on CLL, and CLL Campus

First published: 29 June 2020
COVID-19 among fit patients with CLL treated with venetoclax-based combinations
Moritz Fürstenau, Petra Langerbeins, Nisha De Silva, Anna Maria Fink, Sandra Robrecht, Julia von Tresckow, Florian Simon, Karin Hohloch, Jolanda Droogendijk, Marjolein van der Klift, Ellen van der Spek, Thomas Illmer, Björn Schöttker, Kirsten Fischer, Clemens M. Wendtner, Eugen Tausch, Stephan Stilgenbauer, Carsten U. Niemann, Michael Gregor, Arnon P. Kater, Michael Hallek, & Barbara Eichhorst.
Leukemia (2020)
Please access the full article here

First published: 18 May 2020
Clinical Outcome of Coronavirus Disease 2019 in Haemato‐oncology Patients
James A. Aries, Jeffrey K. Davies, Rebecca L. Auer, Simon L. Hallam, Silvia Montoto, Matthew Smith, Belen Sevillano, Vanessa Foggo, Bela Wrench, Krzysztof Zegocki, Samir Agrawal, Rifca Le Dieu, Edward Truelove, Thomas Erblich, Shamzah Araf, Jessica Okosun, Heather Oakervee, Jamie D. Cavenagh, John G. Gribben, John C. Riches
Summary: The initial reports from China show that patients with cancer are over‐represented among individuals who develop severe Covid‐19 after contracting the virus.(4) Patients with haematological malignancies are expected to be at increased risk of adverse outcomes from this viral infection, due being immunosuppressed as a consequence of the underlying cancer, and from the effects of therapy. Our data demonstrate that while patients with haematological cancers have worse outcomes after Covid-19 than the background population, the majority still survive.
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi:10.1111/bjh.16852
Please access the full article here.

Published in Blood: 17 April 2020
The BTK-inhibitor ibrutinib may protect against pulmonary injury in COVID-19 infected patients
Steven P Treon, Jorge Castillo, Alan P Skarbnik, Jacob D Soumerai, Irene M Ghobrial, Maria Luisa Guerrera, Kirsten E. Meid, Guang Yang
Paper from latest ASH COVID related publications.
Please access the full article here

First published: 7 May 2020
Survival study of hospitalized patients with concurrent Covid‐19 and haematological malignancies
Fernando Martín‐Moro, Juan Marquet, Miguel Piris, Berta M Michael, Adolfo J Sáez, Magdalena Corona, Carlos Jiménez, Beatriz Astibia, Irene García, Eulalia Rodríguez, Carlota García‐Hoz, Jesús Fortún‐Abete, Pilar Herrera, Javier López‐Jiménez
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi:10.1111/bjh.16801
Please access the full article here

First published: 30 April 2020
Management of CLL Patients Early in the COVID‐19 Pandemic: An International Survey of CLL Experts
Brian Koffman, Anthony Mato, John C. Byrd, Alexey Danilov, Brad Hedrick, Chaitra Ujjani, Lindsey Roeker, Deborah M. Stephens, Matthew S. Davids, John M. Pagel, Mazyar Shadman
You can access the full article here.
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/ajh.25851.

Published: 30 April 2020
Covid-19 infection in therapy-naive patients with B-cell chronic lymphocytic leukemia
S. Paneesha,a,b G. Pratt,a,b H. Parry,a,b and P. Mossa,b,⁎
You can access the full article here.

Published: 24 April 2020
COVID-19 in persons with haematological cancers
- Wenjuan He, Lei Chen, Li Chen, Guolin Yuan, Yun Fang, Wenlan Chen, Di Wu, Bo Liang, Xiaoting Lu, Yanling Ma, Lei Li, Hongxiang Wang, Zhichao Chen, Qiubai Li & Robert Peter Gale
You can access the full article here.